Carbon dots as nanocatalytic medicine for anti-inflammation therapy

Bo Kong; Tong Yang; Feng Cheng; Yan Qian; Chunmei Li; Lei Zhan; Yuanfang Li; Hongyan Zou; Chengzhi Huang

doi:10.1016/j.jcis.2021.12.107

Carbon dots as nanocatalytic medicine for anti-inflammation therapy

J Colloid Interface Sci. 2022 Apr:611:545-553. doi: 10.1016/j.jcis.2021.12.107. Epub 2021 Dec 21.

Authors

Bo Kong¹, Tong Yang², Feng Cheng¹, Yan Qian¹, Chunmei Li¹, Lei Zhan¹, Yuanfang Li³, Hongyan Zou⁴, Chengzhi Huang⁵

Affiliations

¹ Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
² Chongqing Key Laboratory of Luminescent and Real-Time Analysis System, Chongqing Science and Technology Commission, College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China; College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan 650500, China.
³ Chongqing Key Laboratory of Luminescent and Real-Time Analysis System, Chongqing Science and Technology Commission, College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China.
⁴ Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. Electronic address: zhy2013@swu.edu.cn.
⁵ Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of Luminescent and Real-Time Analysis System, Chongqing Science and Technology Commission, College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing 400715, China. Electronic address: chengzhi@swu.edu.cn.

PMID: 34971965
DOI: 10.1016/j.jcis.2021.12.107

Abstract

Aberrant reactive oxygen species (ROS) generation is one of the crucial mediators in the pathogenesis of inflammation. So, the development of nanocatalytic medicine to catalyze the ROS-scavenging reactions in pathological regions are promising for anti-inflammatory therapy. Herein, a type of biocompatible metal free carbon dots is prepared via a hydrothermal method which can exhibit peroxidase (POD)-like, catalase (CAT)-like and superoxide dismutase (SOD)-like activities. It has been found that the carbon dots have the capability to efficiently deplete the excessive ROS such as peroxide (H₂O₂)_, superoxide anion (O₂^-) and hydroxyl radical (OH) for their abundant functional groups. After the tail injection in mice with liver inflammation induced by lipopolysaccharide, the carbon dots efficiently reduced the excessive production of ROS and proinflammatory cytokines in vitro. Both in vitro and in vivo results endowed the biocompatible carbon dots with great potential in nanocatalytic medicine for the treatment of disease.

Keywords: Anti-inflammation; Carbon dots; Catalytic medicine; Multienzyme; Reactive oxygen species scavenging.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Carbon*
Hydrogen Peroxide*
Mice
Reactive Oxygen Species
Superoxide Dismutase

Substances

Anti-Inflammatory Agents
Reactive Oxygen Species
Carbon
Hydrogen Peroxide
Superoxide Dismutase