Glycosylated zein as a novel nanodelivery vehicle for lutein

Ying Chang; Yan Jiao; Da-Jing Li; Xiao-Lan Liu; He Han

doi:10.1016/j.foodchem.2021.131927

Glycosylated zein as a novel nanodelivery vehicle for lutein

Food Chem. 2021 Dec 23:376:131927. doi: 10.1016/j.foodchem.2021.131927. Online ahead of print.

Authors

Ying Chang¹, Yan Jiao², Da-Jing Li³, Xiao-Lan Liu¹, He Han¹

Affiliations

¹ College of Food and Bioengineering, Qiqihar University, Qiqihar 161006, China.
² College of Food and Bioengineering, Qiqihar University, Qiqihar 161006, China. Electronic address: jiaoyan_3000@126.com.
³ Institute of Agro-product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

PMID: 34971886
DOI: 10.1016/j.foodchem.2021.131927

Abstract

Glucosamine-glycosylated zein (GLZ) generated by transglutaminase was developed as a novel delivery vehicle to prepare lutein-loaded glycosylated zein nanoparticles (GLZ-LUT). GLZ-LUT exhibited a polydispersed spherical microstructure, lutein was embedded into GLZ to form nanocomplexes via self-assembly, they had a lower zeta potential and an average particle size of less than 200 nm. Compared to lutein-loaded zein nanoparticles (Zein-LUT), the lutein entrapment efficiency of GLZ-LUT was increased from 81.55% to 89.60%. Infrared spectroscopy (FTIR) analysis results confirmed that zein was successfully modified and that lutein was encapsulated by hydrophobic zein and GLZ. Moreover, GLZ showed significantly higher solubilization of lutein than Zein-LUT and significantly improved the in vitro release of lutein in the simulated gastrointestinal tract. The in vitro antioxidant activity of lutein was also enhanced by the encapsulation of zein and glycosylated zein. These findings indicated that GLZ represent a potentially efficient and promising nanodelivery carrier for lutein compounds.

Keywords: Delivery vehicle; Glycosylation; Lutein; Zein.