Biomanufacturing in low Earth orbit for regenerative medicine

Arun Sharma; Rachel A Clemens; Orquidea Garcia; D Lansing Taylor; Nicole L Wagner; Kelly A Shepard; Anjali Gupta; Siobhan Malany; Alan J Grodzinsky; Mary Kearns-Jonker; Devin B Mair; Deok-Ho Kim; Michael S Roberts; Jeanne F Loring; Jianying Hu; Lara E Warren; Sven Eenmaa; Joe Bozada; Eric Paljug; Mark Roth; Donald P Taylor; Gary Rodrigue; Patrick Cantini; Amelia W Smith; Marc A Giulianotti; William R Wagner

doi:10.1016/j.stemcr.2021.12.001

Biomanufacturing in low Earth orbit for regenerative medicine

Stem Cell Reports. 2022 Jan 11;17(1):1-13. doi: 10.1016/j.stemcr.2021.12.001. Epub 2021 Dec 30.

Authors

Arun Sharma¹, Rachel A Clemens², Orquidea Garcia³, D Lansing Taylor⁴, Nicole L Wagner⁵, Kelly A Shepard⁶, Anjali Gupta², Siobhan Malany⁷, Alan J Grodzinsky⁸, Mary Kearns-Jonker⁹, Devin B Mair¹⁰, Deok-Ho Kim¹¹, Michael S Roberts¹², Jeanne F Loring¹³, Jianying Hu¹⁴, Lara E Warren¹², Sven Eenmaa¹², Joe Bozada¹⁵, Eric Paljug¹⁵, Mark Roth¹⁶, Donald P Taylor¹⁷, Gary Rodrigue¹², Patrick Cantini¹⁸, Amelia W Smith¹², Marc A Giulianotti¹⁹, William R Wagner²⁰

Affiliations

¹ Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: arun.sharma@cshs.org.
² Axiom Space, Inc., Houston, TX, USA.
³ Johnson & Johnson 3D Printing Innovation & Customer Solutions, Johnson & Johnson Services, Inc., Irvine, CA, USA.
⁴ University of Pittsburgh Drug Discovery Institute and Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
⁵ LambdaVision Inc., Farmington, CT, USA.
⁶ California Institute for Regenerative Medicine, Oakland, CA, USA.
⁷ Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
⁸ Departments of Biological Engineering, Mechanical Engineering and Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁹ Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA, USA.
¹⁰ Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹¹ Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹² Center for the Advancement of Science in Space, Inc, Melbourne, FL, USA.
¹³ Scripps Research Institute, San Diego, CA, USA.
¹⁴ Center for Computational Health IBM Research, Yorktown Heights, New York, NY, USA.
¹⁵ Joseph M. Katz Graduate School of Business, University of Pittsburgh, Pittsburgh, PA, USA.
¹⁶ Pittsburgh, PA, USA.
¹⁷ The Ohio State University, Columbus, OH, USA.
¹⁸ McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA.
¹⁹ Center for the Advancement of Science in Space, Inc, Melbourne, FL, USA. Electronic address: mgiulianotti@issnationallab.org.
²⁰ McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA; Departments of Surgery, Bioengineering, Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: wagnerwr@upmc.edu.

Abstract

Research in low Earth orbit (LEO) has become more accessible. The 2020 Biomanufacturing in Space Symposium reviewed space-based regenerative medicine research and discussed leveraging LEO to advance biomanufacturing for regenerative medicine applications. The symposium identified areas where financial investments could stimulate advancements overcoming technical barriers. Opportunities in disease modeling, stem-cell-derived products, and biofabrication were highlighted. The symposium will initiate a roadmap to a sustainable market for regenerative medicine biomanufacturing in space. This perspective summarizes the 2020 Biomanufacturing in Space Symposium, highlights key biomanufacturing opportunities in LEO, and lays the framework for a roadmap to regenerative medicine biomanufacturing in space.

Keywords: biofabrication; microgravity; microphysiological systems; organoids; stem cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Artificial Intelligence
Automation
Biocompatible Materials*
Bioengineering
Extraterrestrial Environment*
Humans
Machine Learning
Manufactured Materials*
Regenerative Medicine*
Research

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding