The increase in infections caused by multidrug-resistant microorganisms is currently one of the most serious medical issues. In fact, antimicrobial resistance is viewed by the World Health Organization as one of the most serious threats to health worldwide. The problem is exacerbated by the lack of new antibiotics with respective benefits for the treatment of multidrug-resistant bacteria. While new compounds are being developed a number of "old" antibiotics used in clinical practice for several decades may acquire new indications for use.
Keywords: Escherichia coli; antibiotic resistance; efficacy; fosfomycin; safety; therapy; urinary tract infections.