Puzzling (IRIDA-Like and Hemolytic) Anemia in a Child With Idiopathic Pulmonary Hemosiderosis

J Pediatr Hematol Oncol. 2022 May 1;44(4):191-193. doi: 10.1097/MPH.0000000000002385. Epub 2021 Dec 30.

Abstract

Before the diagnosis of idiopathic pulmonary hemosiderosis (IPH), unexplained or puzzling anemia may precede and delay in the diagnosis of pediatric IPH is common. A 5.8 years old female child initiated with iron-refractory iron deficiency anemia-like iron deficiency and hemolytic anemia and at 6.8 years of age IPH was materialized, when the patient showed the triad signs of IPH with hemosiderin-laden alveolar macrophages in gastric aspirate. Although time to the diagnosis was previously reported to be ranged from 16 to 30 months, in our case it took 12 months from the initial anemia to IPH diagnosis.

MeSH terms

  • Anemia, Hemolytic* / complications
  • Anemia, Hemolytic* / diagnosis
  • Anemia, Iron-Deficiency* / complications
  • Child
  • Child, Preschool
  • Female
  • Hemosiderosis* / complications
  • Hemosiderosis* / diagnosis
  • Hemosiderosis, Pulmonary
  • Humans
  • Lung Diseases* / complications
  • Lung Diseases* / diagnosis

Supplementary concepts

  • Iron-Refractory Iron Deficiency Anemia