Thoracic transplantation during the COVID-19 pandemic

Clin Transplant. 2022 Apr;36(4):e14575. doi: 10.1111/ctr.14575. Epub 2022 Jan 10.

Abstract

The worldwide pandemic caused by COVID-19, resulting from the infection by betacoronarvirus SARS-CoV-2, has dramatically altered healthcare worldwide. Due to the highly contagious nature of SARS-CoV2, coupled with hospitals and intensive care units being overwhelmed, numerous transplant programs either slowed or shut down completely. While there have been isolated reports of COVID-19 in transplant recipients, no study to date has examined how COVID-19 affected actual transplant patterns and outcomes in the United States. Of particular importance is the impact of COVID-19 on mortality in waitlisted patients and transplant recipients. Using the Scientific Registry of Transplant Recipients (SRTR) dataset, we compared waitlist and transplant characteristics from 3/2019-8/2019 to 3/2020-8/2020, as well as COVID-19 associated mortality in patients with prior heart or lung transplant or those active on the waitlist. Overall, there was an initial decrease in transplant volume in April 2020; however, volumes have normalized since then, with comparable outcomes to similar calendar months in 2019. Additionally, there were no significant changes in post-transplant outcomes or waiting list mortality. Given the ongoing COVID-19 pandemic, it would be beneficial to maintain current practices for thoracic transplantation, to continue to provide this life-saving therapy to those in need.

Keywords: COVID-19; heart transplant; lung transplant.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19* / epidemiology
  • Humans
  • Pandemics*
  • RNA, Viral
  • SARS-CoV-2
  • Transplant Recipients
  • United States
  • Waiting Lists

Substances

  • RNA, Viral