Preparation, toxicity reduction and radiation therapy application of gold nanorods

Lina Xie; Xujia Zhang; Chengchao Chu; Yingqi Dong; Tianzi Zhang; Xinyue Li; Gang Liu; Wen Cai; Suxia Han

doi:10.1186/s12951-021-01209-4

Preparation, toxicity reduction and radiation therapy application of gold nanorods

J Nanobiotechnology. 2021 Dec 28;19(1):454. doi: 10.1186/s12951-021-01209-4.

Authors

Lina Xie¹, Xujia Zhang², Chengchao Chu³, Yingqi Dong², Tianzi Zhang², Xinyue Li¹, Gang Liu⁴, Wen Cai⁵, Suxia Han⁶

Affiliations

¹ Department of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
² Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
³ Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
⁴ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, Fujian, China.
⁵ Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. caiwen2016@xjtu.edu.cn.
⁶ Department of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. shan87@mail.xjtu.edu.cn.

Abstract

Gold nanorods (GNRs) have a broad application prospect in biomedical fields because of their unique properties and controllable surface modification. The element aurum (Au) with high atomic number (high-Z) render GNRs ideal radiosensitive materials for radiation therapy and computed tomography (CT) imaging. Besides, GNRs have the capability of efficiently converting light energy to heat in the near-infrared (NIR) region for photothermal therapy. Although there are more and more researches on GNRs for radiation therapy, how to improve their biocompatibility and how to efficiently utilize them for radiation therapy should be further studied. This review will focuse on the research progress regarding the preparation and toxicity reduction of GNRs, as well as GNRs-mediated radiation therapy.

Keywords: Gold nanorods (GNRs); Preparation; Radiation sensitization; Radiation therapy; Toxicity reduction.

Publication types

Review

MeSH terms

Animals
Gold / chemistry*
Gold / therapeutic use
Gold / toxicity
Humans
Hyperthermia, Induced
Nanotubes / chemistry*
Nanotubes / toxicity
Photosensitizing Agents / chemistry*
Photosensitizing Agents / therapeutic use*
Photosensitizing Agents / toxicity
Photothermal Therapy
Radiotherapy*

Substances

Photosensitizing Agents
Gold

Abstract

Publication types

MeSH terms

Substances

Grants and funding