Recent Advances in Chronotherapy Targeting Respiratory Diseases

Keshav Raj Paudel; Saurav Kumar Jha; Venkata Sita Rama Raju Allam; Parteek Prasher; Piyush Kumar Gupta; Rahul Bhattacharjee; Niraj Kumar Jha; Sukriti Vishwas; Sachin K Singh; Jesus Shrestha; Mohammad Imran; Nisha Panth; Dinesh Kumar Chellappan; Majid Ebrahimi Warkiani; Philip M Hansbro; Kamal Dua

doi:10.3390/pharmaceutics13122008

Recent Advances in Chronotherapy Targeting Respiratory Diseases

Pharmaceutics. 2021 Nov 25;13(12):2008. doi: 10.3390/pharmaceutics13122008.

Authors

Keshav Raj Paudel^{1

2}, Saurav Kumar Jha³, Venkata Sita Rama Raju Allam⁴, Parteek Prasher⁵, Piyush Kumar Gupta⁶, Rahul Bhattacharjee⁷, Niraj Kumar Jha⁸, Sukriti Vishwas⁹, Sachin K Singh⁹, Jesus Shrestha¹⁰, Mohammad Imran¹¹, Nisha Panth¹, Dinesh Kumar Chellappan¹², Majid Ebrahimi Warkiani^{10

13}, Philip M Hansbro^{1

2}, Kamal Dua^{1

14}

Affiliations

¹ Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia.
² School of Life Sciences, University of Technology Sydney, Sydney, NSW 2007, Australia.
³ Department of Biomedicine, Health and Life Convergence Sciences, BK21 Four, Biomedical and Healthcare Research Institute, Mokpo National University, Muan 58554, Korea.
⁴ Department of Medical Biochemistry and Microbiology, Uppsala University, 75237 Uppsala, Sweden.
⁵ Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, Uttarakhand, India.
⁶ Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida 201310, Uttar Pradesh, India.
⁷ Kalinga Institute of Industrial Technology (KIIT-DU), KIIT School of Biotechnology, Bhubaneswar 751024, Odisha, India.
⁸ Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida 201310, Uttar Pradesh, India.
⁹ School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi Grand Trunk Road, Phagwara 144411, Punjab, India.
¹⁰ School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
¹¹ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, Delhi, India.
¹² School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia.
¹³ Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia.
¹⁴ Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia.

Abstract

Respiratory diseases contribute to a significant percentage of mortality and morbidity worldwide. The circadian rhythm is a natural biological process where our bodily functions align with the 24 h oscillation (sleep-wake cycle) process and are controlled by the circadian clock protein/gene. Disruption of the circadian rhythm could alter normal lung function. Chronotherapy is a type of therapy provided at specific time intervals based on an individual's circadian rhythm. This would allow the drug to show optimum action, and thereby modulate its pharmacokinetics to lessen unwanted or unintended effects. In this review, we deliberated on the recent advances employed in chrono-targeted therapeutics for chronic respiratory diseases.

Keywords: asthma; chronic obstructive pulmonary disease; chronotherapy; circadian rhythm; lung cancer; pulmonary fibrosis.

Publication types

Review