Objective: To examine the clinical effect of minimally invasive duodenum preserving pancreatic head resection(DPPHR) for benign and pre-malignant lesions of pancreatic head. Methods: The clinical data of patients with diagnosis of benign or pre-malignant pancreatic head tumor were retrospectively collected and analyzed,all of them underwent laparoscopic or robotic DPPHR between October 2015 and September 2021 at Division of Gastrointestinal and Pancreatic surgery,Zhejiang Provincial People's Hospital. Thirty-three patients were enrolled with 10 males and 23 females. The age(M(IQR)) was 54(32) years old(range: 11 to 77 years old) and the body mass index was 21.9(2.9)kg/m2(range: 18.1 to 30.1 kg/m2). The presenting symptoms included abdominal pain(n=12), Whipple triad(n=2), and asymptomatic(n=19). There were 7 patients with hypertension and 1 patient with diabetes mellitus. There were 19 patients who were diagnosed as American Society of Anesthesiologists class Ⅰ and 14 patients who were diagnosed as class Ⅱ. The student t test,U test, χ2 test or Fisher exact test was used to compare continuous data or categorized data,respectively. All the perioperative data and metabolic morbidity were analyzed and experiences on minimally invasive DPPHR were concluded. Results: Fourteen patients underwent laparoscopic DPPHR,while the rest of 19 patients received robotic DPPHR. Indocyanine green fluorescence imaging was used in 19 patients to guide operation. Five patients were performed pancreatico-gastrostomy and the rest 28 patients underwent pancreaticojejunostomy. Pathological outcomes confirmed 9 solid pseudo-papillary neoplasms, 9 intraductal papillary mucinous neoplasms, 7 serous cystic neoplasms, 6 pancreatic neuroendocrine tumors, 1 mucous cystic neoplasm, 1 chronic pancreatitis. The operative time was (309.4±50.3) minutes(range:180 to 420 minutes),and the blood loss was (97.9±48.3)ml(range:20 to 200 ml). Eighteen patients suffered from postoperative complications,including 3 patients experienced severe complications(Clavien-Dindo Grade ≥Ⅲ). Pancreatic fistula occurred in 16 patients,including 8 patients with biochemical leak,7 patients with grade B pancreatic fistula and 1 patient with grade C pancreatic fistula. No one suffered from the duodenal necrosis and none perioperative death was occurred. The length of hospital stay was 14(7) days (range:6 to 87 days). The follow-up was 22.6(24.5)months(range:2 to 74 months). None suffered from recurrence or metastasis. During the follow-up,all the patients were free of refractory cholangitis. Moreover,in the term of endocrine dysfunction,no postoperative new onset of diabetes mellitus were observed in the long-term follow-up. However,in the view of exocrine insufficiency,pancreatic exocrine insufficiency and non-alcoholic fatty liver disease (NAFLD) was complicated in 2 and 1 patient,respectively,with the supplement of pancreatic enzyme,steatorrhea and weight loss relieved,but NAFLD was awaited to be seen. Conclusions: Minimally invasive DPPHR is feasible and safe for benign or pre-malignant lesions of pancreatic head. Moreover,it is oncological equivalent to pancreaticoduodenectomy with preservation of metabolic function without refractory cholangitis.
目的： 探讨微创保留十二指肠的胰头切除术（DPPHR）治疗胰头良性和交界性肿瘤的临床效果。 方法： 回顾性分析2015年10月至2021年9月于浙江省人民医院胃肠胰外科因胰头良性或交界性肿瘤行腹腔镜或机器人DPPHR的33例患者资料。男性10例，女性23例，年龄［M（IQR）］54（32）岁（范围：11~77岁），体重指数21.9（2.9）kg/m2（范围：18.1~30.1 kg/m2）。临床症状：腹痛12例，Whipple三联征2例，无症状因体检发现19例。合并高血压7例，糖尿病1例。美国麻醉医师协会评分：Ⅰ级19例，Ⅱ级14例。定量资料的组间比较采用Student t检验或U检验；分类资料的组间比较采用χ²检验或Fisher确切概率法。 结果： 33例患者中，14例行腹腔镜DPPHR，19例行机器人DPPHR。重建方式：胰胃吻合5例，胰肠吻合28例。术后病理学检查结果显示，导管内乳头状黏液腺瘤9例，实性假乳头状瘤9例，浆液性囊腺瘤7例，神经内分泌瘤6例，黏液性囊腺瘤1例，慢性胰腺炎1例。手术时间（309.4±50.3）min（范围：180~420 min），术中出血量（97.9±48.3）ml（范围：20~200 ml）。围手术期出现并发症18例，其中3例出现严重并发症（Clavien-Dindo并发症分级≥Ⅲ级）。发生胰瘘16例，其中生化漏8例，B级胰瘘7例，C级胰瘘1例。无围手术期死亡病例。术后住院14（7）d（范围：6~87 d）。术后随访22.6（24.5）个月（范围：2~74个月），未见肿瘤复发，2例出现脂肪泻伴体重下降，1例于术后12个月并发非酒精性脂肪性肝病，无术后新发糖尿病。所有患者术后均未出现胆道狭窄及反流性胆管炎。 结论： 微创DPPHR治疗胰头良性和交界性肿瘤是可行的，可保留更多的胰腺内外分泌功能，避免胆道并发症。.