A review on the toxicity of silver nanoparticles against different biosystems

Ramachandran Rajan; PeiPei Huo; Krishnaraj Chandran; Balakumaran Manickam Dakshinamoorthi; Soon-Il Yun; Bo Liu

doi:10.1016/j.chemosphere.2021.133397

A review on the toxicity of silver nanoparticles against different biosystems

Chemosphere. 2022 Apr:292:133397. doi: 10.1016/j.chemosphere.2021.133397. Epub 2021 Dec 23.

Authors

Ramachandran Rajan¹, PeiPei Huo¹, Krishnaraj Chandran², Balakumaran Manickam Dakshinamoorthi³, Soon-Il Yun⁴, Bo Liu⁵

Affiliations

¹ Laboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo, Shandong, 255000, PR China.
² Department of Food Science and Technology, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju, 54896, Republic of Korea; Department of Agricultural Convergence Technology, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju, 54896, Republic of Korea.
³ Department of Biotechnology, Dwaraka Doss Goverdhan Doss Vaishnav College, Chennai, 600106, Tamil Nadu, India.
⁴ Department of Food Science and Technology, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju, 54896, Republic of Korea; Department of Agricultural Convergence Technology, College of Agriculture and Life Sciences, Jeonbuk National University, Jeonju, 54896, Republic of Korea. Electronic address: siyun@jbnu.ac.kr.
⁵ Laboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo, Shandong, 255000, PR China. Electronic address: liub@sdut.edu.cn.

PMID: 34954197
DOI: 10.1016/j.chemosphere.2021.133397

Abstract

Despite significant progress made in the past two decades, silver nanoparticles (AgNPs) have not yet made it to the clinical trials. In addition, they showed both positive and negative effects in their toxicity from unicellular organism to well-developed multi-organ system, for example, rat. Although it is generally accepted that capped (bio)molecules have synergistic bioactivities and diminish the toxicity of metallic Ag core, convincing evidence is completely lacking. Therefore, in this review, we first highlight the recent in vivo toxicity studies of chemically manufactured AgNPs, biologically synthesized AgNPs and reference AgNPs of European Commission. Then, their toxic effects are compared with each other and the overlooked factors leading to the potential conflict of obtained toxicity results are discussed. Finally, suggestions are given to better design and conduct the future toxicity studies and to fast-track the successful clinical translation of AgNPs as well.

Keywords: Bio-AgNPs; Chem-AgNPs; Conflict; NM-300; NM-300 K; Overlooked factors.

Publication types

Review

MeSH terms

Animals
Metal Nanoparticles* / toxicity
Rats
Silver* / toxicity

Substances

Silver