Methods for the analysis of endocrine disrupting chemicals in selected environmental matrixes

Environ Res. 2022 Apr 15:206:112616. doi: 10.1016/j.envres.2021.112616. Epub 2021 Dec 23.

Abstract

Endocrine disrupting chemicals (EDCs) are heterogenous in structure, chemical and physical properties, and their capacity to partition into various environmental matrixes. In many cases, these chemicals can disrupt the endocrine systems of vertebrate and invertebrate organisms when present at very low concentrations. Therefore, sensitive and varied analytical methods are required to detect these compounds in the environment. This review summarizes the analytical methods and instruments that are most used to monitor for EDCs in selected environmental matrixes. Only those matrixes for which there is a clear link between exposures and endocrine effects are included in this review. Also discussed are emerging methods for sample preparation and advanced analytical instruments that provide greater selectivity and sensitivity.

Keywords: Analysis; Endocrine disrupting chemicals; GC-MS; LC-MS/MS.

Publication types

  • Review

MeSH terms

  • Endocrine Disruptors* / analysis
  • Endocrine Disruptors* / toxicity
  • Endocrine System
  • Water Pollutants, Chemical* / analysis

Substances

  • Endocrine Disruptors
  • Water Pollutants, Chemical