Bioaccumulation as a mechanism of microbiome/drug interactions

Ziv Cohen; Libusha Kelly

doi:10.1016/j.tim.2021.12.003

Bioaccumulation as a mechanism of microbiome/drug interactions

Trends Microbiol. 2022 Feb;30(2):99-101. doi: 10.1016/j.tim.2021.12.003. Epub 2021 Dec 21.

Authors

Ziv Cohen¹, Libusha Kelly²

Affiliations

¹ Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10641, USA.
² Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10641, USA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10641, USA. Electronic address: libusha.kelly@einsteinmed.org.

PMID: 34952771
DOI: 10.1016/j.tim.2021.12.003

Abstract

Microbes of the human gut can change drug disposition in the human body and gut ecology via 'bioaccumulation', a process in which bacteria take up compounds intracellularly without chemically modifying them or experiencing changes in growth, as described in Klünemann et al. This work expands current understanding of the types of drug-bacterial interactions in the gut environment.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Bacteria
Bioaccumulation
Drug Interactions
Gastrointestinal Microbiome*
Humans
Microbiota*

Abstract

Publication types

MeSH terms

Grants and funding