Genetic Polymorphisms of Very Important Pharmacogene Variants in the Blang Population from Yunnan Province in China

Yuliang Wang; Linna Peng; Hongyan Lu; Zhanhao Zhang; Shishi Xing; Dandan Li; Chunjuan He; Tianbo Jin; Li Wang

doi:10.2147/PGPM.S327313

Genetic Polymorphisms of Very Important Pharmacogene Variants in the Blang Population from Yunnan Province in China

Pharmgenomics Pers Med. 2021 Dec 17:14:1647-1660. doi: 10.2147/PGPM.S327313. eCollection 2021.

Authors

Yuliang Wang^{1

2

3}, Linna Peng^{1

2

3}, Hongyan Lu^{1

2

3}, Zhanhao Zhang^{1

2

3}, Shishi Xing^{1

2

3}, Dandan Li^{1

2

3}, Chunjuan He^{1

2

3}, Tianbo Jin^{1

2

3}, Li Wang^{1

2

3}

Affiliations

¹ Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082, Shaanxi, People's Republic of China.
² Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, People's Republic of China.
³ Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, People's Republic of China.

Abstract

Background: We aimed to enrich the pharmacogenomic information of a Blang population (BP) from Yunnan Province in China.

Methods: We genotyped 55 very important pharmacogene (VIP) variants from the PharmGKB database and compared their genotype distribution (GD) in a BP with that of 26 populations by the χ ² test. The minor allele frequency (MAF) distribution of seven significantly different single-nucleotide polymorphisms (SNPs) was conducted to compare the difference between the BP and 26 other populations.

Results: Compared with the GD of 55 loci in the BP, among 26 studied populations, GWD, YRI, GIH, ESN, MSL, TSI, PJL, ACB, FIN and IBS were the top-10 populations, which showed a significantly different GD >35 loci. CHB, JPT, CDX, CHS, and KHV populations had a significantly different GD <20 loci. A GD difference of 27-34 loci was found between the BP and 11 populations (LWK, CEU, ITU, STU, PUR, CLM, GBR, ASW, BEB, MXL and PEL). The GD of five loci (rs750155 (SULT1A1), rs4291 (ACE), rs1051298 (SLC19A1), rs1131596 (SLC19A1) and rs1051296 (SLC19A1)) were the most significantly different in the BP as compared with that of the other 26 populations. The genotype frequency of rs1800764 (ACE) and rs1065852 (CYP2D6) was different in all populations except for PEL and LWK, respectively. MAFs of rs1065852 (CYP2D6) and rs750155 (SULT1A1) showed the largest fluctuation between the BP and SAS, EUR, AFR and AMR populations.

Conclusion: Our data can provide theoretical guidance for safe and efficacious personalized drug use in the Blang population.

Keywords: Blang population; SNP; genotype distribution; personalized drug use; pharmacogenomics; single-nucleotide polymorphism; very important pharmacogene.

Grants and funding

The study was supported by the Talent Development Supporting Project entitled Tibet-Shaanxi Himalaya of Xizang Minzu University (2020 Plateau Scholar), Major Science and Technology Research Projects of Xizang (Tibet) Autonomous Region (2015XZ01G23), and Natural Science Foundation of Tibet Autonomous Region (2015ZR-13-19).