Metanalysis on the effectiveness of low back pain treatment with oxygen-ozone mixture: Comparison between image-guided and non-image-guided injection techniques

Gustas Rimeika; Luca Saba; Ganesan Arthimulam; Luigi Della Gatta; Kristina Davidovic; Matteo Bonetti; Donatella Franco; Camilla Russo; Mario Muto

doi:10.1016/j.ejro.2021.100389

Metanalysis on the effectiveness of low back pain treatment with oxygen-ozone mixture: Comparison between image-guided and non-image-guided injection techniques

Eur J Radiol Open. 2021 Dec 6:8:100389. doi: 10.1016/j.ejro.2021.100389. eCollection 2021.

Authors

Gustas Rimeika¹, Luca Saba², Ganesan Arthimulam³, Luigi Della Gatta⁴, Kristina Davidovic⁵, Matteo Bonetti⁶, Donatella Franco⁷, Camilla Russo⁴, Mario Muto⁴

Affiliations

¹ Department of Radiology, Nuclear Medicine and Medical Physics, Vilnius University, Vilnius, Lithuania.
² Department of Radiology, Azienda Ospedaliera Universitaria di Cagliari-Polo di Monserrato, Cagliari, Italy.
³ Interventional Radiology Unit, Department of Diagnostic Imaging, Kuala Lumpur General Hospital, Malaysia.
⁴ Department of Neuroradiology, A.O.R.N. Cardarelli, Naples, Italy.
⁵ Clinical Centre of Serbia, Institute for Radiology, Emergency Room Department, Serbia.
⁶ Department of Neuroradiology, Istituto Clinico Città di Brescia, Italy.
⁷ Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Abstract

Low back pain (LBP) is a common disorder affecting an increasing number of people worldwide, whose diagnosis is focused on the identification of triggering causes. First line therapy usually starts from conservative approaches, whereas second line treatments include a spectrum of minimally invasive techniques, before resorting to more invasive surgical approaches. Among minimally invasive techniques, percutaneous oxygen-ozone injections represent one of the most common and cost-effective procedures. Aim of this study is to provide a metanalysis on literature evidences on percutaneous oxygen-ozone injections, comparing image-guided to non-image-guided techniques for LBP treatment. Imaging-guided procedures showed better performances compared to non-image-guided techniques based only on anatomical landmarks, with higher therapeutic efficacy and lower age-related variability in clinical results.

Keywords: BPI, Brief Pain Inventory; CT, Computed Tomography; Chemodiscolysis; DSA, Digital Subtraction Angiography; IF, Impact Factor; LBP, Low back pain; LDH, Lumbar Disc Hernia; Low back pain; Lumbar disc herniation; MRI, Magnetic Resonance Imaging; Meta-analysis; ODI, Oswestry Disability Index; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines; Pain; Percutaneous oxygen-ozone injection; RMDQ, Roland Morris Disability Questionnaire; Sciatica; US, ultrasonography; VAS, Visual Analogue Scale for pain.

Publication types

Review