In 1940 during the early phase of the Nazi aerial assault on Britain, the English neurophysiologist, C.S. Sherrington, age 83 years, had just published a philosophical work, Man on His Nature, and was researching the writings of Jean Fernel, a 16th century French physician. Sherrington's study of Fernel stemmed from a common interest they shared in the association between the mind and the brain. This essay was prompted by a short letter penned by Sherrington in December 1940 and bound years later in his biography, The Endeavour of Jean Fernel, published in 1946. The letter requested information about a particular medical work by Fernel but also mentioned in passing Sherrington's recent forced evacuation from his home in Ipswich, threatened by German bombing and invasion. The letter in the book invited a reprise of his remarkable career and a study of his last neurological concern - the mind-brain mystery.
Keywords: C.S. Sherrington; Jean Fernel; mind-brain connection; neurophysiology; reflex activity.