Long non-coding RNA XIST: a novel oncogene in multiple cancers

Jun Yang; Manlong Qi; Xiang Fei; Xia Wang; Kefeng Wang

doi:10.1186/s10020-021-00421-0

Long non-coding RNA XIST: a novel oncogene in multiple cancers

Mol Med. 2021 Dec 20;27(1):159. doi: 10.1186/s10020-021-00421-0.

Authors

Jun Yang¹, Manlong Qi², Xiang Fei³, Xia Wang³, Kefeng Wang⁴

Affiliations

¹ Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
² Department of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
³ Department of Urology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping, Liaoning, 110004, Shenyang, China.
⁴ Department of Urology, Shengjing Hospital of China Medical University, #36 Sanhao Street, Heping, Liaoning, 110004, Shenyang, China. wang.kefeng@hotmail.com.

Abstract

Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected and analyzed the recent studies on the impact of XIST in human tumor development. The multilevel molecular functions of XIST in human tumors are comprehensively reviewed to clarify the pathologic mechanisms and to offer a novel direction for further study.

Keywords: Cancer; Long non-coding RNA; Oncogene; XIST.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Neoplasms / genetics*
Oncogenes*
RNA, Long Noncoding*

Substances

RNA, Long Noncoding
XIST non-coding RNA