Characteristics of preeclampsia in donor cell gestations

Attina Ervaala; Hannele Laivuori; Mika Gissler; Juha Kere; Katja Kivinen; Anneli Pouta; Eero Kajantie; Seppo Heinonen; Satu Wedenoja

doi:10.1016/j.preghy.2021.12.005

Characteristics of preeclampsia in donor cell gestations

Pregnancy Hypertens. 2022 Mar:27:59-61. doi: 10.1016/j.preghy.2021.12.005. Epub 2021 Dec 11.

Authors

Attina Ervaala¹, Hannele Laivuori², Mika Gissler³, Juha Kere⁴, Katja Kivinen⁵, Anneli Pouta⁶, Eero Kajantie⁷, Seppo Heinonen¹, Satu Wedenoja⁸

Affiliations

¹ Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
² Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, 33520 Tampere, Finland; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
³ Information Services Department, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
⁴ Stem Cells and Metabolism Research Program, University of Helsinki, and Folkhälsan Research Center, 00290 Helsinki, Finland; Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden.
⁵ Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland.
⁶ Information Services Department, Finnish Institute for Health and Welfare, 00300 Helsinki, Finland.
⁷ PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, 90570 Oulu, Finland; Public Health Promotion Unit, Finnish Institute for Health and Welfare, 00300 Helsinki and 90220 Oulu, Finland; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway; Children's Hospital, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland.
⁸ Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland; Stem Cells and Metabolism Research Program, University of Helsinki, and Folkhälsan Research Center, 00290 Helsinki, Finland. Electronic address: satu.wedenoja@helsinki.fi.

PMID: 34929557
DOI: 10.1016/j.preghy.2021.12.005

Abstract

Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07-3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02-6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.

Keywords: In vitro fertilization; Ovum donation; Preeclampsia; Pregnancy; Sperm donation.

MeSH terms

Adult
Case-Control Studies
Cohort Studies
Female
Humans
Oocyte Donation / adverse effects
Oocyte Donation / statistics & numerical data*
Pre-Eclampsia / epidemiology*
Pre-Eclampsia / etiology
Pre-Eclampsia / immunology
Pregnancy
Risk Factors
Sperm Injections, Intracytoplasmic / adverse effects
Sperm Injections, Intracytoplasmic / statistics & numerical data