Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Jiawen Chen; Tianyu Sun; Yan You; Buling Wu; Xiaofang Wang; Jingyi Wu

doi:10.3389/fcell.2021.760532

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Front Cell Dev Biol. 2021 Nov 30:9:760532. doi: 10.3389/fcell.2021.760532. eCollection 2021.

Authors

Jiawen Chen¹, Tianyu Sun², Yan You¹, Buling Wu^{1

3}, Xiaofang Wang⁴, Jingyi Wu⁵

Affiliations

¹ School of Stomatology, Southern Medical University, Guangzhou, China.
² Department of Periodontology, Stomatological Hospital, Southern Medical University, Guangzhou, China.
³ Department of Endodontics, Shenzhen Stomatology Hospital, Southern Medical University, Shenzhen, China.
⁴ Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, United states.
⁵ Center of Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou, China.

Abstract

Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.

Keywords: differentiation; glycosaminoglyans; mesenchymal stem cell; osteogenesis; proteoglycan; self-renewal; stem cell homeostasis; tissue engineering.

Publication types

Review