Fabrication of adhesive hydrogels based on poly (acrylic acid) and modified hyaluronic acid

Xiumei Zhang; Huining Wan; Weiwei Lan; Fenyan Miao; Miao Qin; Yan Wei; Yinchun Hu; Ziwei Liang; Di Huang

doi:10.1016/j.jmbbm.2021.105044

Fabrication of adhesive hydrogels based on poly (acrylic acid) and modified hyaluronic acid

J Mech Behav Biomed Mater. 2022 Feb:126:105044. doi: 10.1016/j.jmbbm.2021.105044. Epub 2021 Dec 11.

Authors

Xiumei Zhang¹, Huining Wan², Weiwei Lan¹, Fenyan Miao¹, Miao Qin¹, Yan Wei³, Yinchun Hu¹, Ziwei Liang¹, Di Huang⁴

Affiliations

¹ Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, Shanxi Key Laboratory of Materials Strength & Structural Impact, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, PR China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan, 030032, PR China.
² Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, Shanxi Key Laboratory of Materials Strength & Structural Impact, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, PR China.
³ Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, Shanxi Key Laboratory of Materials Strength & Structural Impact, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, PR China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan, 030032, PR China. Electronic address: weiyan@tyut.edu.cn.
⁴ Department of Biomedical Engineering, Research Center for Nano-Biomaterials & Regenerative Medicine, Shanxi Key Laboratory of Materials Strength & Structural Impact, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, PR China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan, 030032, PR China. Electronic address: huangjw2067@163.com.

PMID: 34915359
DOI: 10.1016/j.jmbbm.2021.105044

Abstract

Hydrogel wound dressings with good flexibility and adhesiveness to resist deformation during wound movement are urgently needed in clinical application. In this work, the hydrogels based on poly (acrylic acid) and N-hydroxysuccinimide grafted hyaluronic acid (PAA/HA_-NHS) with good elasticity and adhesiveness were prepared by chemical cross-linking and hydrogen bonding. The elastic and adhesive properties within the PAA hydrogels could reach a balance by adjusting the concentration of potassium persulfate (KPS) and N, N'-methylenebisacrylamide (MBA). Subsequently, HA_-NHS was incorporated into the PAA hydrogel system. The mechanical test revealed that the elongation at break and interfacial toughness of the PAA/HA_-NHS hydrogels could reach 265.79 ± 21.93% and 52.88 ± 3.51 J/m², respectively. In addition, the hydrogels possess a connected porous network and well water absorption ability (with porosity of 51.90 ± 0.11% and swelling ratio in wet state of 122.17 ± 2.78%). In vitro experiment demonstrates that the PAA/HA_-NHS hydrogels exhibit nontoxic and cell in-adhesive properties. The PAA/HA_-NHS hydrogels could cover the wound spots directly, stretch with the skin movement and gently remove from the wound tissue due to the suitable adhesiveness and poor cell adhesion. In conclusion, the PAA/HA_-NHS hydrogels show great application value in the field of wound dressing.

Keywords: Elasticity and adhesiveness; N-hydroxysuccinimide grafted hyaluronic acid; Poly (acrylic acid).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylates
Adhesives
Hyaluronic Acid*
Hydrogels*
Wound Healing

Substances

Acrylates
Adhesives
Hydrogels
Hyaluronic Acid
acrylic acid