Polylactic acid/polyvinyl alcohol-quaternary ammonium chitosan double-layer films doped with novel antimicrobial agent CuO@ZIF-8 NPs for fruit preservation

Dongsheng Fu; Yuanzheng Ding; Ruijie Guo; Jie Zhang; Huifang Wang; Baolong Niu; Hong Yan

doi:10.1016/j.ijbiomac.2021.12.022

Polylactic acid/polyvinyl alcohol-quaternary ammonium chitosan double-layer films doped with novel antimicrobial agent CuO@ZIF-8 NPs for fruit preservation

Int J Biol Macromol. 2022 Jan 15:195:538-546. doi: 10.1016/j.ijbiomac.2021.12.022. Epub 2021 Dec 14.

Authors

Dongsheng Fu¹, Yuanzheng Ding², Ruijie Guo³, Jie Zhang¹, Huifang Wang⁴, Baolong Niu¹, Hong Yan⁵

Affiliations

¹ College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Ministry of Education, Taiyuan 030024, China.
² Department of Clinical Medicine, Fenyang college of Shanxi Medical University, Fenyang 032200, China.
³ College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Ministry of Education, Taiyuan 030024, China. Electronic address: guoruijie@tyut.edu.cn.
⁴ Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Ministry of Education, Taiyuan 030024, China.
⁵ College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China; Key Laboratory of Interface Science and Engineering in Advanced Materials, Taiyuan University of Technology, Ministry of Education, Taiyuan 030024, China. Electronic address: yanhong@tyut.edu.cn.

PMID: 34914914
DOI: 10.1016/j.ijbiomac.2021.12.022

Abstract

ZIF-8, a subclass of metal organic frameworks (MOFs), was employed as the CuO carriers because of its high surface areas and good dispersibility. A novel antibacterial agent CuO@ZIF-8 was synthesized by environmentally-friendly direct calcination strategy, and introduced into the composite double-layer films for packing materials. The double-layer films were prepared via solution casting method with polylactic acid (PLA) and polyvinyl alcohol (PVA)-quaternary ammonium chitosan as the matrix of outer layer and inner layer, respectively; and CuO@ZIF-8 nanoparticles were introduced into the PVA-quaternary ammonium chitosan layer. The double-layer films exhibited superior antibacterial activity resulted from the uniform dispersion of CuO by ZIF-8 carriers. The elongation at break was enhanced and up to 17.13%, about 2.4-fold that of PLA films. Meanwhile, the films provided low water vapor permeability and strong UV-barrier ability which were attributed to the lay-by-layer casting, CuO@ZIF-8 doping and TiO₂ addition. Cherry tomato preservation experiment revealed that the composite films retarded the growth of harmful microorganisms on the fruit surface. MTT assay confirmed the cytocompatibility of the films. The easily fabricated double-layer films presented potential possibility in the field of biodegradable food packaging.

Keywords: Antibacterial; Composite double-layer films; CuO; MOFs; Polylactic acid (PLA); Polyvinyl alcohol (PVA).

MeSH terms

Ammonium Compounds / chemistry*
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology*
Chemical Phenomena
Chitosan / chemistry*
Food Preservation*
Fruit
Mechanical Phenomena
Microbial Sensitivity Tests
Nanoparticles*
Polyesters / chemistry*
Polyvinyl Alcohol / chemistry*
Spectrum Analysis

Substances

Ammonium Compounds
Anti-Infective Agents
Polyesters
poly(lactide)
Polyvinyl Alcohol
Chitosan