This overview of severe acute respiratory syndrome coronavirus 2 circulation over 1.5 years in Guinea demonstrates that virus clades and variants of interest and concern were progressively introduced, mostly by travellers through Conakry, before spreading through the country. Sequencing is key to following virus evolution and establishing efficient control strategies.
Keywords: COVID-19; Guinea; SARS-CoV-2; West Africa; complete genome sequencing; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; variants; viruses; zoonoses.