Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

Wanying Lu; Guoliang Zhu; Weize Yuan; Zhaoxi Han; Huanqin Dai; Mostafa Basiony; Lixin Zhang; Xueting Liu; Tom Hsiang; Jingyu Zhang

doi:10.1016/j.synbio.2021.10.001

Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

Synth Syst Biotechnol. 2021 Nov 30;6(4):446-451. doi: 10.1016/j.synbio.2021.10.001. eCollection 2021 Dec.

Authors

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.
² The State Key Laboratory of Mycology (SKLM), Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
³ School of Environmental Sciences, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

Abstract

Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B (1 and 2), together with one previously characterized sesquiterpenoid lignoren (3) were identified. Structures of 1-3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis, S. aureus, and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 μM).

Keywords: Aliphatic unsaturated alcohols; Antibacterial; Natural products; Pathogenic fungus.