The unresolved question on COVID-19 virus origin: The three cards game?

J Med Virol. 2022 Apr;94(4):1257-1260. doi: 10.1002/jmv.27519. Epub 2021 Dec 19.

Abstract

The ongoing discussion about the real origin of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) feeds acrimonious debates. Where did SARS-CoV-2 come from? Was SARS-CoV-2 transmitted in the wild from an animal to a person before exploding in Wuhan or was it an engineered virus that escaped from research or a laboratory in Wuhan? Right now, we still don't know enough whether SARS-CoV-2 is human-made or not, and lab-leak theories remain essentially speculative. Many recent studies have pointed out several plausible scenarios. Anyhow, currently, even if suspicions by some about the possibility of lab-leak hypothesis still remain, the consensus view is that the pandemic probably started from a natural source and, to determine the real origin of the SARS-CoV-2 virus, further research is needed.

Keywords: SARS coronavirus; coronavirus; epidemiology; pandemics; virus classification.

MeSH terms

  • Animals
  • Betacoronavirus / genetics
  • Betacoronavirus / isolation & purification
  • Biological Evolution
  • COVID-19 / epidemiology
  • COVID-19 / transmission
  • COVID-19 / virology*
  • Humans
  • Laboratories
  • SARS-CoV-2 / genetics*
  • SARS-CoV-2 / isolation & purification
  • Viral Zoonoses / epidemiology
  • Viral Zoonoses / transmission
  • Viral Zoonoses / virology