Clinical presentation, treatment, and genetic and histopathological analysis of juvenile cataracts and secondary glaucoma in a rhesus macaque (Macaca mulatta)

M Isabel Casanova; Rui Chen; Laura M Garzel; Katherine J Olstad; Soohyun Kim; Ronald Alan Harris; Yumei Li; Muthuswamy Raveendran; Qingnan Liang; Jun Wang; Glenn Yiu; John Timothy Stout; Jeffrey A Roberts; Jeffrey Rogers; Ala Moshiri; Sara M Thomasy

doi:10.1111/jmp.12560

Clinical presentation, treatment, and genetic and histopathological analysis of juvenile cataracts and secondary glaucoma in a rhesus macaque (Macaca mulatta)

J Med Primatol. 2022 Apr;51(2):119-123. doi: 10.1111/jmp.12560. Epub 2021 Dec 12.

Authors

M Isabel Casanova¹, Rui Chen^{2

3}, Laura M Garzel⁴, Katherine J Olstad⁴, Soohyun Kim¹, Ronald Alan Harris², Yumei Li², Muthuswamy Raveendran², Qingnan Liang^{2

3}, Jun Wang², Glenn Yiu⁵, John Timothy Stout⁶, Jeffrey A Roberts^{4

7}, Jeffrey Rogers², Ala Moshiri⁵, Sara M Thomasy^{1

4

5}

Affiliations

¹ Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.
² Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
³ Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
⁴ California National Primate Research Center, Davis, California, USA.
⁵ Department of Ophthalmology & Vision Science, School of Medicine, University of California Davis, Sacramento, California, USA.
⁶ Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.
⁷ Medicine and Epidemiology Department, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

Abstract

This report describes the clinical and histological findings, genetic study, and treatment in a 1.3-year-old rhesus macaque with bilateral cataracts and unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased the intraocular pressure from 56 to <2 mm Hg. A putative genetic cause of the cataracts was not identified.

Keywords: chronic glaucoma; intravitreal gentamicin; non-human primate.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Animals
Cataract* / diagnosis
Cataract* / genetics
Cataract* / veterinary
Glaucoma* / genetics
Glaucoma* / veterinary
Intraocular Pressure
Macaca mulatta / genetics

Abstract

Publication types

MeSH terms

Grants and funding