SARS-Cov-2 pneumonia and concurrent myelodysplasia complicated by Pseudomonas aeruginosa over-infection

Aldo Pezzuto; Antonella Tammaro; Giuseppe Tonini; Giulia Conforti; Francesca Falangone; Valerio Spuntarelli; Antonella Teggi; Alfredo Pennica

doi:10.1016/j.jviromet.2021.114419

SARS-Cov-2 pneumonia and concurrent myelodysplasia complicated by Pseudomonas aeruginosa over-infection

J Virol Methods. 2022 Feb:300:114419. doi: 10.1016/j.jviromet.2021.114419. Epub 2021 Dec 10.

Authors

Aldo Pezzuto¹, Antonella Tammaro², Giuseppe Tonini³, Giulia Conforti⁴, Francesca Falangone⁵, Valerio Spuntarelli⁶, Antonella Teggi⁷, Alfredo Pennica⁸

Affiliations

¹ Cardiovascular-Respiratory Science Department, Sant'Andrea Hospital-Sapienza University, Via di Grottarossa, 1035/39, 00189, Rome, Italy. Electronic address: pezzutoaldo@libero.it.
² Department of Neurosciences, Mental Health and Sensory Organs [NESMOS], Sapienza University of Rome, Via di Grottarossa 1035, 00189, Rome, Italy. Electronic address: antonella.tammaro@uniroma1.it.
³ Oncology Department, University Campus-Medico, via Alvaro Del Portillo, 00128, Roma, Italy. Electronic address: g.tonini@unicampus.it.
⁴ Internal Medicine Department Sant'Andrea Hospital, Sapienza University, 00189, Rome, Italy. Electronic address: giulia.conforti@uniroma1.it.
⁵ Internal Medicine Department Sant'Andrea Hospital, Sapienza University, 00189, Rome, Italy. Electronic address: francesca.falangone@uniroma1.it.
⁶ Internal Medicine Department Sant'Andrea Hospital, Sapienza University, 00189, Rome, Italy. Electronic address: valerio.spuntarelli@uniroma1.it.
⁷ Infectious Disease Unit-S Andrea Hospital, Sapienza University, Rome, Italy. Electronic address: antonella.teggi@ospedalesantandrea.it.
⁸ Infectious Disease Unit-S Andrea Hospital, Sapienza University, Rome, Italy. Electronic address: alfredo.pennica@uniroma1.it.

Abstract

The new virus called severe acute respiratory syndrome coronavirus 2 (SARSCov-2) causing Coronavirus disease 2019 (COVID-19) has spread quickly in several countries and it has become pandemic. Different types of clinical manifestations are attributed to this infection. Some mechanisms related to the infection regarding the immune response are not still elucidated. Herein we reported a case of a 66-years-old patient affected by myelodysplasia who was referred to our hospital because of clinical and radiological manifestations of viral pneumonia. The clinical course has become complicated due to bacterial secondary over-infection by Pseudomonas aeruginosa during stay in internal medicine unit whilst a persistent positive oral and naso-pharyngeal swab test was reported up to 100 days of admission. The patient had a fast clinical and radiological worsening that led her to be admitted to an intensive care unit. Despite intubation and mechanical ventilation she died in a few days.

Keywords: Bacterial over-infection; Myelodysplasia; SARS-Cov-2 pneumonia.

Publication types

Case Reports

MeSH terms

Aged
COVID-19*
Female
Humans
Pandemics
Pseudomonas aeruginosa
Retrospective Studies
SARS-CoV-2*