Measurement of Hansen Solubility Parameters of third-degree burn eschar

Maryam Hosseini; Michael S Roberts; Reza Aboofazeli; Hamid R Moghimi

doi:10.1016/j.burns.2021.07.017

Measurement of Hansen Solubility Parameters of third-degree burn eschar

Burns. 2022 Jun;48(4):860-871. doi: 10.1016/j.burns.2021.07.017. Epub 2021 Aug 3.

Authors

Maryam Hosseini¹, Michael S Roberts², Reza Aboofazeli³, Hamid R Moghimi⁴

Affiliations

¹ Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Therapeutics Research Centre, School of Medicine, Translational Research Institute, University of Queensland, Brisbane 4102, Australia; School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia.
³ Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: hrmoghimi@yahoo.com.

PMID: 34893367
DOI: 10.1016/j.burns.2021.07.017

Abstract

Topical drug therapy is one of the most effective approaches in third-degree burn wound treatments. To optimize and enhance drug permeation through burn eschar, we need to characterize this barrier, most importantly, its affinity to drugs; the subject of this investigation. Hansen Solubility Parameters (HSP), as polarity and affinity scale, were measured here for human third-degree burn eschar through uptake studies using 19 solvents at 25 °C and 32 °C and two hydration levels by gravimetric method combined with thermal analysis and Karl Fischer titration. HSP parameters of dispersion (δ_D), bipolar (δ_P), and hydrogen bonding (δ_H) were calculated by HSPiP software. Results showed δ_D, δ_P, and δ_H of 17.0, 12.5, 14.6 and 16.8, 12.4, 14.4 at 25 and 32 °C respectively for normally-hydrated samples. Full hydration increased HSP values to 17.2, 12.9, 15.3 (25 °C) and 17.1, 12.8, 15.1 (32 °C). Good correlations between solvents uptakes and HSP values were observed for all parameters; higher for δ_P. Increased temperature decreased them with more changes in δ_H. Relative Energy Differences (RED) were calculated and shown to be a good parameter for predicting drug-eschar affinity. The obtained information is useful for drug selection and carrier design in drug delivery through burn eschar.

Keywords: Hansen Solubility Parameter; Hydration; Permeation; Polarity; Third-degree burn eschar.

MeSH terms

Burns* / therapy
Excipients
Humans
Pharmaceutical Preparations
Soft Tissue Injuries*
Solubility
Solvents

Substances

Excipients
Pharmaceutical Preparations
Solvents