Compliant mechanisms are frequently used in the design of prosthetic fingers since their monolithic structure and flexible movement are quite similar to the biological human fingers. However, the design of compliant prosthetic fingers is not easy, as the conventional rigid-link-based mechanism theory cannot be directly applied. In this paper, we introduce a 3D topology optimization based design framework to simplify the synthesis process of bionic compliant prosthetic fingers. The proposed framework is implemented in the software MATLAB and the realized fingers can be quickly fabricated using selective laser sintering (SLS) technology. To illustrate the design process of the proposed framework, a design example was presented. The bending performance of the realized finger was successfully verified by the FEM-based simulation and the payload test. In future work, the optimized fingers have the potential to be integrated into prosthetic hands to realize sophisticated grasping movements.