EEG can be used to characterize the electrical activity of the cerebral cortex, but it is also susceptible to interference. Compared with the other artifacts, Electrooculogram (EOG) artifacts have a greater impact on EEG processing and are more difficult to remove. Here, we mainly compared the regression and ICA algorithms both based on the EOG channels for the effect of removing EOG artifacts in the Stroop experiment of methamphetamine addicts. From the perspective of time domain and power spectral density, the ICA algorithm based on the EOG channels is more effective. However, the regression algorithm based on the EOG channels is less complex, more time-saving, and more suitable for real-time tasks.Clinical Relevance- For clinical purposes, this research has a certain reference value for selecting appropriate methods of removing EOG artifacts when processing the EEG of methamphetamine addicts.