The frequency content of a sound changes the perception of acoustic features, but can headphones also change auditory information interpretation? Audio devices such as headphones are factors that have not been taken into consideration at studying sound perception, specifically in acoustic therapies. In particular, alternative treatments based on psychoacoustic effects could be more effective if the frequency response of headphones is found as a determining factor.This investigation, therefore, aims to study the brain response (in terms of electroencephalographic activity) produced by listening to pink noise in three different headphone models. Furthermore, not only the immediate response is studied, but the sound habituation (after daily exposure to pink noise for 30 days) is also investigated. The investigation findings reveal that headphones with a flatter frequency response provide more accurate acoustic information to the brain, what in turn, demands a larger number and a wider variety of mental resources, even after a habituation process.Clinical Relevance-This investigation establishes that audio devices are a determining factor to achieve specific psychoacoustic effects since they change the auditory information decoding at a cortical level.