Electronic skin has aroused extensive research interest due to high similarity with human skin. Realizing a multifunctional electronic skin that is highly consistent with skin functions and endowed with more other functions is now a more urgent need and important challenge. Here, we use 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized cellulose nanofibril (TOCN) dispersion and highly conductive Ti3C2TX dispersion to prepare TOCN/Ti3C2TX composite film through vacuum-assisted filtration. The obtained composite film imitating the nacre-like lamellar structure of natural shells has good mechanical properties (124.6 MPa of tensile strength). Meanwhile, the composite film also showed excellent electromagnetic shielding performance (36 dB), biocompatibility, and antibacterial properties. In addition, the piezoresistive sensor assembled from the composite film exhibited a high sensitivity (11.6 kPa-1), fast response and recovery time (≤10 ms), ultralow monitoring limit (0.2 Pa), and long-term stability (>10 000 cycles). It also could detect human daily activities such as finger bent, chewing, and so on.