Metabolic Interactions Between Tumor and Stromal Cells in the Tumor Microenvironment

Deepshikha Mishra; Debabrata Banerjee

doi:10.1007/978-3-030-83282-7_5

Metabolic Interactions Between Tumor and Stromal Cells in the Tumor Microenvironment

Adv Exp Med Biol. 2021:1350:101-121. doi: 10.1007/978-3-030-83282-7_5.

Authors

Deepshikha Mishra¹, Debabrata Banerjee²

Affiliations

¹ Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA. mishradeepshikha21@gmail.com.
² Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA. banerjed@rutgers.edu.

PMID: 34888846
DOI: 10.1007/978-3-030-83282-7_5

Abstract

In this chapter, we provide information about metabolic reprogramming in cancer cells, molecular interactions between tumor and stromal cells in the tumor microenvironment, focusing primarily on CAFs and tumor cell interaction. We have covered the role of cytokines, chemokines, and lactate in driving tumor-stroma interactions in the microenvironment. Here, we have discussed the pro-tumorigenic molecular interactions in between tumor cells and CAFs mediated via altered signaling pathways, cytokines, chemokines, and lactate in the tumor vicinity. A better understanding of the complex cancer cell-CAF interactions will help in designing successful therapeutic strategies targeting the stromal-rich tumors in the clinic.

Keywords: CAFs; Cytokines; Lactate; Metabolic cooperation; Pyruvate; Tumor microenvironment.

MeSH terms

Cancer-Associated Fibroblasts*
Cell Communication
Humans
Neoplasms*
Stromal Cells
Tumor Microenvironment