Nanoarchitectonics for Abused-Drug Biosensors

Rasoul Moradi; Nazila Pour Khalili; Ni Luh Wulan Septiani; Chia-Hung Liu; Esmail Doustkhah; Yusuke Yamauchi; Slava V Rotkin

doi:10.1002/smll.202104847

Nanoarchitectonics for Abused-Drug Biosensors

Small. 2022 Mar;18(10):e2104847. doi: 10.1002/smll.202104847. Epub 2021 Dec 9.

Authors

Rasoul Moradi^{1

2}, Nazila Pour Khalili^{1

3}, Ni Luh Wulan Septiani⁴, Chia-Hung Liu^{5

6}, Esmail Doustkhah^{7

8}, Yusuke Yamauchi^{8

9}, Slava V Rotkin¹⁰

Affiliations

¹ Nanotechnology Laboratory, School of Engineering and Applied Science, Khazar University, Baku, Az1096, Azerbaijan.
² Department of Chemical Engineering, School of Engineering and Applied Science, Khazar University, Baku, Az1096, Azerbaijan.
³ Center for Cell Pathology Research, Department of Biological Science, Khazar University, Baku, Az1096, Azerbaijan.
⁴ Advanced Functional Materials Research Group, Institut Teknologi Bandung, Bandung, 40132, Indonesia.
⁵ Department of Urology, School of Medicine, College of Medicine, and TMU Research Center of Urology and Kidney, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei, 110, Taiwan.
⁶ Department of Urology, Shuang Ho Hospital, Taipei Medical University, No. 291, Zhongzheng Road, Zhonghe District, New Taipei City, 23561, Taiwan.
⁷ International Center for Materials Nanoarchitechtonics (WPI-MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
⁸ JST-ERATO Yamauchi Materials Space-Tectonics Project and International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
⁹ School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia.
¹⁰ Department of Engineering Science and Mechanics, Materials Research Institute, The Pennsylvania State University, Millennium Science Complex, University Park, PA, 16802, USA.

PMID: 34882957
DOI: 10.1002/smll.202104847

Abstract

Rapid, accessible, and highly accurate biosensors for the detection of addictive and abused drugs are needed to reduce the adverse personal and societal impacts of addiction. Modern sensors that utilize next-generation technologies, e.g., nanobiotechnology and nanoarchitectonics, have triggered revolutionary progress in the field as they allow accurate detection and tracking of trace levels of major classes of drugs. This paper reviews advances in the field of biosensors for the detection of commonly abused drugs, both prescribed such as codeine and morphine, and illegal narcotics like cocaine.

Keywords: abused drug detection; aptamers; biosensors; nanoarchitectonics; nanoarchitecture.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biosensing Techniques*
Cocaine*
Illicit Drugs*
Morphine

Substances

Illicit Drugs
Morphine
Cocaine