Recent advances in T-cell lymphoid neoplasms

Exp Hematol. 2022 Feb:106:3-18. doi: 10.1016/j.exphem.2021.12.191. Epub 2021 Dec 5.

Abstract

T Cells comprise many subtypes of specified lymphocytes, and their differentiation and function take place in different tissues. This cellular diversity is also observed in the multiple ways T-cell transformation gives rise to a variety of T-cell neoplasms. This review covers the main types of T-cell malignancies and their specific characteristics, emphasizing recent advances at the cellular and molecular levels as well as differences and commonalities among them.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chromosome Aberrations
  • Humans
  • Leukemia, T-Cell / genetics
  • Leukemia, T-Cell / metabolism
  • Leukemia, T-Cell / pathology*
  • Leukemia, T-Cell / therapy
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / metabolism
  • Lymphoma, T-Cell / pathology*
  • Lymphoma, T-Cell / therapy
  • Mutation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Signal Transduction
  • T-Lymphocytes / metabolism
  • T-Lymphocytes / pathology*