COVID-19: Post-recovery long-term symptoms among patients in Saudi Arabia

PLoS One. 2021 Dec 8;16(12):e0260259. doi: 10.1371/journal.pone.0260259. eCollection 2021.

Abstract

Background: After recovery from acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many patients experience long-term symptoms in different body systems. The aim of the present study was to identify these symptoms, their severity, and their duration as a first step in building a system to classify post-recovery long-term symptoms of coronavirus disease 2019 (COVID-19).

Methods: An online-based cross-sectional survey was administered between September and October 2020. Data regarding the severity of post-recovery symptoms and their duration were collected using an Arabic questionnaire divided into six categories encompassing the 20 most prevalent symptoms.

Results: A total of 979 patients recovered from COVID-19 in Saudi Arabia in the study period, of whom 53% were male and 47% were female. The most common symptoms included general fatigue and weakness (73% each), with moderate severity of neurological symptoms including mood changes (41%) and insomnia (39%). Among the special senses, loss of smell and taste of marked severity were reported by 64% and 55% among respiratory symptoms, cough of mild severity (47%), and dyspnea of moderate severity (43%). Loss of appetite of moderate severity was reported in 42%, and diarrhea, abdominal pain, and nausea of mild severity were reported by 53%, 50%, and 44% of respondents, respectively.

Conclusions: Long-term symptoms after recovery from COVID-19 warrant patient follow-up. The authors propose a classification system as a starting point to guide the identification and follow-up of long-term symptoms post-recovery, and recommend larger-scale studies to broaden the definition of recovery from COVID-19, which appears to have two phases, acute and chronic.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • COVID-19 / complications
  • COVID-19 / epidemiology
  • COVID-19 / pathology*
  • COVID-19 / virology
  • Child
  • Cough / etiology
  • Cross-Sectional Studies
  • Fatigue / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mood Disorders / etiology
  • SARS-CoV-2 / isolation & purification
  • Saudi Arabia / epidemiology
  • Severity of Illness Index
  • Sleep Initiation and Maintenance Disorders / etiology
  • Surveys and Questionnaires
  • Young Adult

Grants and funding

The authors received no specific funding for this work.