Electrochemical dopamine sensor based on bi-metallic Co/Zn porphyrin metal-organic framework

Abstract

Integrating other metal ions into mono-metallic metal-organic framework (MOF) to form bi-metallic MOF is an effective strategy to enhance the performance of MOFs from the internal structure. In this study, two-dimensional (2D) cobalt/zinc-porphyrin (Co/Zn-TCPP) MOF nanomaterials with different Co/Zn molar ratios were synthesised using a simple surfactant-assisted method, and novel dopamine (DA) sensing methods were constructed based on these materials. The characterisation results showed that all MOF with different Co/Zn molar ratios presented a nanofilm, and the Co and Zn elements were uniformly distributed. All sensors based on Co_xZn_100-x-TCPP had a certain catalytic performance to DA. Among them, the sensor based on CO₂₅Zn₇₅-TCPP showed the strongest signal response, indicating that the catalytic performance of MOF on DA can be adjusted by changing the Co/Zn molar ratio. The doping of metal ions improves the chemical environment of the pores, and increases the types and spatial arrangement of the active sites of the MOF, which is beneficial to the electron transfer and exchange with DA; Co²⁺ and Zn²⁺ active centres have a synergistic promotion effect, so the catalytic activity of MOF is significantly improved. The linear range at the potential of 0.1 V based on Co₂₅Zn₇₅-TCPP for DA was 5 nM-177.8 μM, with a detection limit of 1.67 nM (S/N = 3). The sensor exhibited a good selectivity for detecting DA. This research is expected to provide new ideas and references for constructing high-performance sensing interfaces and platforms.

Keywords: Bimetal organic frame; Dopamine; Electrochemical sensing; Performance control; Surfactant-assisted preparation method.