SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters

Peter J Halfmann; Noriko Nakajima; Yuko Sato; Kenta Takahashi; Molly Accola; Shiho Chiba; Shufang Fan; Gabriele Neumann; William Rehrauer; Tadaki Suzuki; Yoshihiro Kawaoka

doi:10.1093/infdis/jiab587

SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters

J Infect Dis. 2022 Jan 18;225(2):282-286. doi: 10.1093/infdis/jiab587.

Authors

Affiliations

¹ Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
² Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
³ UW Health Clinical Laboratories, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA.
⁴ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
⁵ Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Abstract

In hamsters, SARS-CoV-2 infection at the same time as or before H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates. This interference may be correlated with SARS-CoV-2-induced expression of MX1.

Keywords: MX1; Coinfection; Influenza; SARS-CoV-2; antiviral.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
COVID-19*
Coinfection
Cricetinae
Humans
Influenza A Virus, H3N2 Subtype*
Mesocricetus
Myxovirus Resistance Proteins / metabolism*
SARS-CoV-2*
Virus Replication*

Substances

Myxovirus Resistance Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding