Long-Term Stress and Trait Anxiety Affect Brain Network Balance in Dynamic Cognitive Computations

Abstract

Long-term stress has a profound impact on executive functions. Trait anxiety is recognized as a vulnerable factor accounting for stress-induced adaptive or maladaptive effects. However, the neurocognitive mechanisms underlying long-term stress and trait anxiety interactions remain elusive. Here we investigated how long-term stress and trait anxiety interact to affect dynamic decisions during n-back task performance by altering functional brain network balance. In comparison to controls, participants under long-term stress experienced higher psychological distress and exhibited faster evidence accumulation but had a lower decision-threshold when performing n-back tasks in general. This corresponded with hyper-activation in the anterior insula, less deactivation in the default-mode network, and stronger default-mode network decoupling with the frontoparietal network. Critically, high trait anxiety under long-term stress led to slower evidence accumulation through higher frontoparietal activity during cognitively demanding task, and increased decoupling between the default-mode and frontoparietal networks. Our findings suggest a neurocognitive model of how long-term stress and trait anxiety interplay to affect latent dynamic computations in executive functioning with adaptive and maladaptive changes, and inform personalized assessments and preventions for stress vulnerability.

Keywords: anxiety; dynamic decision; functional magnetic resonance imaging; network balance; stress.