piRBase: integrating piRNA annotation in all aspects

Jiajia Wang; Yirong Shi; Honghong Zhou; Peng Zhang; Tingrui Song; Zhiye Ying; Haopeng Yu; Yanyan Li; Yi Zhao; Xiaoxi Zeng; Shunmin He; Runsheng Chen

doi:10.1093/nar/gkab1012

piRBase: integrating piRNA annotation in all aspects

Nucleic Acids Res. 2022 Jan 7;50(D1):D265-D272. doi: 10.1093/nar/gkab1012.

Authors

Jiajia Wang^{1

2

3

4}, Yirong Shi^{3

5}, Honghong Zhou^{1

2

3}, Peng Zhang^{3

6}, Tingrui Song³, Zhiye Ying^{1

2}, Haopeng Yu^{1

2}, Yanyan Li^{1

2

3}, Yi Zhao^{1

2

7}, Xiaoxi Zeng^{1

2}, Shunmin He^{1

2

3

4

6}, Runsheng Chen^{1

2

3

6

8}

Affiliations

¹ West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu 610041, China.
² Med-X Center for Informatics, Sichuan University, Chengdu 610041, China.
³ Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
⁴ College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
⁵ University of Chinese Academy of Sciences, Beijing 100049, China.
⁶ National Genomics Data Center, Chinese Academy of Sciences, Beijing 100101, China.
⁷ Key Laboratory of Intelligent Information Processing, Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100190, China.
⁸ Guangdong Geneway Decoding Bio-Tech Co. Ltd, Foshan 528316, China.

Abstract

Piwi-interacting RNAs are a type of small noncoding RNA that have various functions. piRBase is a manually curated resource focused on assisting piRNA functional analysis. piRBase release v3.0 is committed to providing more comprehensive piRNA related information. The latest release covers >181 million unique piRNA sequences, including 440 datasets from 44 species. More disease-related piRNAs and piRNA targets have been collected and displayed. The regulatory relationships between piRNAs and targets have been visualized. In addition to the reuse and expansion of the content in the previous version, the latest version has additional new content, including gold standard piRNA sets, piRNA clusters, piRNA variants, splicing-junction piRNAs, and piRNA expression data. In addition, the entire web interface has been redesigned to provide a better experience for users. piRBase release v3.0 is free to access, browse, search, and download at http://bigdata.ibp.ac.cn/piRBase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Databases, Nucleic Acid*
Datasets as Topic
Genome*
Humans
Internet
Molecular Sequence Annotation
Multigene Family
RNA Splicing
RNA, Small Interfering / classification
RNA, Small Interfering / genetics*
RNA, Small Interfering / metabolism
User-Computer Interface*

Substances

RNA, Small Interfering