Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Timo Burster; Zhadyra Mustafa; Dinara Myrzakhmetova; Anuar Zhanapiya; Michal Zimecki

doi:10.3389/fchem.2021.784003

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Front Chem. 2021 Nov 15:9:784003. doi: 10.3389/fchem.2021.784003. eCollection 2021.

Authors

Timo Burster¹, Zhadyra Mustafa¹, Dinara Myrzakhmetova¹, Anuar Zhanapiya¹, Michal Zimecki²

Affiliations

¹ Department of Biology, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, Kazakhstan.
² Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

Abstract

During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.

Keywords: COVID-19; SARS-CoV-2; cathepsin G; neutrophil elastase; proteinase 3; serine protease inhibitors; serine proteases; thrombosis.

Publication types

Review