Increased 68 Ga-PSMA-11 Bone Marrow and Splenic Uptake in a Case of Erythroid Myelodysplasia

Maria Isabella Donegani; Stefano Raffa; Alberto Miceli; Silvia Morbelli; Matteo Bauckneht

doi:10.1007/s13139-021-00718-2

Increased 68 Ga-PSMA-11 Bone Marrow and Splenic Uptake in a Case of Erythroid Myelodysplasia

Nucl Med Mol Imaging. 2021 Dec;55(6):323-324. doi: 10.1007/s13139-021-00718-2. Epub 2021 Oct 20.

Authors

Maria Isabella Donegani¹, Stefano Raffa¹, Alberto Miceli¹, Silvia Morbelli^{1

2}, Matteo Bauckneht²

Affiliations

¹ Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
² Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Abstract

We describe the case of an 82-year-old man who underwent ⁶⁸ Ga-prostate-specific membrane antigen-11 (⁶⁸ Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) for the restaging of prostate carcinoma. ⁶⁸ Ga-PSMA-11 PET/CT unexpectedly showed increased tracer uptake homogenously involving the axial and appendicular bone marrow and the spleen, not characteristic for metastatic prostate disease. Further investigations revealed that 2 months before the patient underwent bone marrow biopsy, which showed the occurrence of monolinear myelodysplasia.

Keywords: Myelodysplasia; PET/CT; Prostate-specific membrane antigen.