From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Zi-Wei Zhou; Hui-Zhi Long; Yan Cheng; Hong-Yu Luo; Dan-Dan Wen; Li-Chen Gao

doi:10.3389/fmicb.2021.767931

From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

Front Microbiol. 2021 Nov 15:12:767931. doi: 10.3389/fmicb.2021.767931. eCollection 2021.

Authors

Zi-Wei Zhou^{1

2}, Hui-Zhi Long^{1

2}, Yan Cheng^{1

2}, Hong-Yu Luo^{1

2}, Dan-Dan Wen¹, Li-Chen Gao^{1

2}

Affiliations

¹ Department of Pharmacy, Cancer Institute, Phase I Clinical Trial Centre, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Hengyang, China.
² Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang, China.

Abstract

Cervical cancer is the third leading cause of cancer-related death worldwide. Microbes and hosts form a mutually beneficial symbiosis relationship, and various parts of the host body are microbial habitats. Microbes can trigger inflammation in certain parts of the host body, contributing to cervical cancer development. This article reviews the relationship between cervicovaginal microbes, inflammation and cervical cancer, and discusses the effect of some key cervical microbes on cervical cancer. Finally, probiotic therapy and immunotherapy are summarized.

Keywords: cervical cancer; immunotherapy; inflammation; microbiome; probiotic.

Publication types

Review