Bringing vascularization into glioblastoma in vitro models

Catarina Pacheco; Fátima Baltazar; Bruno M Costa; Bruno Sarmento

doi:10.1016/j.molmed.2021.11.001

Bringing vascularization into glioblastoma in vitro models

Trends Mol Med. 2022 Feb;28(2):84-86. doi: 10.1016/j.molmed.2021.11.001. Epub 2021 Dec 2.

Authors

Catarina Pacheco¹, Fátima Baltazar², Bruno M Costa², Bruno Sarmento³

Affiliations

¹ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal.
² Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3Bs-PT Government Associate Laboratory, Braga/Guimaraes, Portugal.
³ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address: bruno.sarmento@ineb.up.pt.

PMID: 34865985
DOI: 10.1016/j.molmed.2021.11.001

Abstract

Tumor blood vessels create optimal conditions for glioblastoma (GBM) growth and therapy resistance. Therefore, tissue engineering techniques evolved towards allowing its inclusion in preclinical in vitro GBM models. In comparison with conventional ones, less representative of tumor biology, these new tools might significantly improve GBM treatment, contributing to a higher throughput screening in drug research and to the clinical translation of these therapies.

Keywords: glioblastoma; in vitro models; neovascularization; perivascular niche; tissue engineering.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms* / drug therapy
Brain Neoplasms* / therapy
Cell Line, Tumor
Glioblastoma* / drug therapy
Glioblastoma* / therapy
Humans
Neovascularization, Pathologic
Tissue Engineering