Lineage switch to acute myeloid leukemia during induction chemotherapy for early T-cell precursor acute lymphoblastic leukemia with the translocation t(6;11)(q27;q23)/KMT2A-AFDN: A case report

Leuk Res. 2022 Jan:112:106758. doi: 10.1016/j.leukres.2021.106758. Epub 2021 Nov 25.
No abstract available

Keywords: Acute myeloid leukemia; Early T-cell precursor leukemia; KMT2A-AFDN; Lineage switch.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Acute Disease
  • Adolescent
  • Cell Lineage / genetics
  • Chromosome Painting / methods
  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 6 / genetics
  • Female
  • Gene Rearrangement
  • Histone-Lysine N-Methyltransferase / genetics*
  • Humans
  • Induction Chemotherapy / methods
  • Kinesins / genetics*
  • Leukemia, Myeloid / genetics*
  • Leukemia, Myeloid / pathology
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Myosins / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Translocation, Genetic*

Substances

  • AFDN protein, human
  • KMT2A protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase
  • Myosins
  • Kinesins