Nanoparticle theranostics in cardiovascular inflammation

Neil MacRitchie; Valentina Di Francesco; Miguel Filipe Moreira Marques Ferreira; Tomasz J Guzik; Paolo Decuzzi; Pasquale Maffia

doi:10.1016/j.smim.2021.101536

Nanoparticle theranostics in cardiovascular inflammation

Semin Immunol. 2021 Aug:56:101536. doi: 10.1016/j.smim.2021.101536. Epub 2021 Nov 30.

Authors

Neil MacRitchie¹, Valentina Di Francesco², Miguel Filipe Moreira Marques Ferreira², Tomasz J Guzik³, Paolo Decuzzi², Pasquale Maffia⁴

Affiliations

¹ Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. Electronic address: Neil.MacRitchie@glasgow.ac.uk.
² Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, Genoa, Italy.
³ Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Department of Internal Medicine, Jagiellonian University, Collegium Medicum, Kraków, Poland.
⁴ Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy. Electronic address: Pasquale.Maffia@glasgow.ac.uk.

Abstract

Theranostics, literally derived from the combination of the words diagnostics and therapy, is an emerging field of clinical and preclinical research, where contrast agents, drugs and diagnostic techniques are combined to simultaneously diagnose and treat pathologies. Nanoparticles are extensively employed in theranostics due to their potential to target specific organs and their multifunctional capacity. In this review, we will discuss the current state of theranostic nanomedicine, providing key examples of its application in the imaging and treatment of cardiovascular inflammation.

Keywords: Atherosclerosis; Cardiovascular disease; Inflammation; Myocardial infarction; Nanoparticles; Theranostics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Humans
Inflammation
Nanomedicine* / methods
Nanoparticles* / therapeutic use
Precision Medicine
Theranostic Nanomedicine / methods

Abstract

Publication types

MeSH terms

Grants and funding