New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis

Chem Commun (Camb). 2022 Jan 4;58(3):383-386. doi: 10.1039/d1cc05700f.

Abstract

An oxidative photocyclisation of N-arylenaminones to indoles is described, that mirrors the Fischer indole synthesis but uses anilines in place of arylhydrazines. Its value is exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.