Host-guest type multiple site fluorescent probe for GSH detection in living organisms

Tao Liu; Yongkang Yue; Yunze Zhai; Zilong Guo; Wenjing Zhao; Xufeng Yang; Dongdong Chen; Caixia Yin

doi:10.1039/d1cc05494e

Host-guest type multiple site fluorescent probe for GSH detection in living organisms

Chem Commun (Camb). 2021 Dec 16;57(100):13764-13767. doi: 10.1039/d1cc05494e.

Authors

Tao Liu¹, Yongkang Yue², Yunze Zhai³, Zilong Guo³, Wenjing Zhao¹, Xufeng Yang¹, Dongdong Chen¹, Caixia Yin²

Affiliations

¹ Department of Chemistry and Chemical Engineering, Lvliang University, Lvliang 033001, P. R. China.
² Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, P. R. China. yincx@sxu.edu.cn.
³ School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China.

PMID: 34859795
DOI: 10.1039/d1cc05494e

Abstract

The host-guest type molecular size matching strategy, which embodied intramolecular hydrogen bond, aromatic nucleophilic substitution and nucleophilic addition, was utilized to develop a fluorescent probe for GSH specific detection and in situ imaging in organisms.

MeSH terms

Animals
Coumarins / chemistry*
Fluorescent Dyes / chemistry*
Glutathione / analysis*
Glutathione / chemistry
HeLa Cells
Humans
Male
Mice
Mice, Inbred BALB C
Microscopy, Confocal
Microscopy, Fluorescence

Substances

Coumarins
Fluorescent Dyes
Glutathione