Mitochondrial homeostasis is maintained in the absence of autophagy

Abstract

Autophagy is a central recycling process, and it plays a complex role in cancer. We discovered that when autophagy is blocked, cancer cells compensate by increasing mitochondrial-derived vesicles. However, there are many unanswered questions remaining, particularly in the context of the dual roles of autophagy in cancer.

Keywords: Autophagy; cancer; mitochondria; mitochondrial derived vesicles; mitophagy.