The roads to ferroptosis under homeostatic versus pathological conditions

Vincent Chen; Chu Bo; Wei Gu

doi:10.1080/23723556.2021.1970477

The roads to ferroptosis under homeostatic versus pathological conditions

Mol Cell Oncol. 2021 Oct 6;8(5):1970477. doi: 10.1080/23723556.2021.1970477. eCollection 2021.

Authors

Vincent Chen¹, Chu Bo¹, Wei Gu¹

Affiliation

¹ Institute for Cancer Genetics, and Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA.

Abstract

The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for ferroptosis during stress responses. Our results implicate iPLA2β as an essential regulator in a noncanonical ferroptosis pathway.

Keywords: Ferroptosis; iPLA2β; lipid peroxidation; p53.

Abstract

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