The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

Duo Yang; Na Zhang; Meihua Li; Tao Hong; Wei Meng; Taohui Ouyang

doi:10.3389/fonc.2021.772134

The Hippo Signaling Pathway: The Trader of Tumor Microenvironment

Front Oncol. 2021 Nov 11:11:772134. doi: 10.3389/fonc.2021.772134. eCollection 2021.

Authors

Duo Yang¹, Na Zhang², Meihua Li³, Tao Hong³, Wei Meng³, Taohui Ouyang³

Affiliations

¹ Department of the Forth Clinical Medical College of Nanchang University, Nanchang, China.
² Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
³ Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Abstract

The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other pathways complicates its role. Accumulated evidence has shown that the bidirectional interactions between tumor cells and tumor microenvironment (TME) are the premises of tumor occurrence, development, and metastasis. The relationship among different components of the TME constitutes a three-dimensional network. We point out the core position of the Hippo pathway in this network and discuss how the regulatory inputs cause the chain reaction of the network. We also discuss the important role of Hippo-TME involvement in cancer treatment.

Keywords: Hippo pathway; cancer; immune modulation; microenvironment; molecular network.

Publication types

Review