Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

Xingxiang Pu; Sa Yang; Yan Xu; Bolin Chen; Qianzhi Wang; Qian Gong; Lin Wu

doi:10.3389/fonc.2021.702887

Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

Front Oncol. 2021 Nov 11:11:702887. doi: 10.3389/fonc.2021.702887. eCollection 2021.

Authors

Xingxiang Pu¹, Sa Yang², Yan Xu¹, Bolin Chen¹, Qianzhi Wang¹, Qian Gong³, Lin Wu¹

Affiliations

¹ Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
² Department of Pharmacy, Xiangxiang People's Hospital, Xiangxiang, China.
³ Department of Pharmacy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Abstract

The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.

Keywords: cancer of unknown primary; gene expression profiling; immunohistochemistry; real-time PCR; tissue of origin.

Publication types

Case Reports